Behavioral and Immune Responses to Infection Require Gαq- RhoA Signaling in C. elegans

@inproceedings{McMullan2012BehavioralAI,
  title={Behavioral and Immune Responses to Infection Require Gαq- RhoA Signaling in C. elegans},
  author={Rachel McMullan and Alexandra L Anderson and Stephen J. Nurrish},
  booktitle={PLoS pathogens},
  year={2012}
}
Following pathogen infection the hosts' nervous and immune systems react with coordinated responses to the danger. A key question is how the neuronal and immune responses to pathogens are coordinated, are there common signaling pathways used by both responses? Using C. elegans we show that infection by pathogenic strains of M. nematophilum, but not exposure to avirulent strains, triggers behavioral and immune responses both of which require a conserved Gαq-RhoGEF Trio-Rho signaling pathway… CONTINUE READING
17 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Table of Contents.

  • Decrepitus W. Picker
  • Oral surgery, oral medicine, oral pathology and…
  • 2017
Highly Influenced
4 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…