Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression.

@article{Hu2010BehavioralA,
  title={Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression.},
  author={Hongtai Hu and Lan Su and Yaqian Xu and H Zhang and Louis William Wang},
  journal={Neuroscience},
  year={2010},
  volume={169 1},
  pages={171-81}
}
We investigated changes in behavior and brain glucose metabolism in a rat chronic mild stress (CMS) model of depression. The CMS model has been used to mimic depression in humans by using various chronic mild stressors in a 4 weeks period. In the present study, we have developed a combination of tests examining behavior (open field test) and hedonic measure (sucrose preference test) after exposure to CMS, and compared this to control non-stressed rats. We found that CMS induced behavioral… CONTINUE READING

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