Behavioral activating effects of adrafinil in aged canines.


Adrafinil, a vigilance enhancing pharmaceutical, was administered to aged dogs for 14 consecutive days at doses of 10, 20, 30, or 40 mg/kg using a crossover design. The effects on spontaneous behavior in a 10-min canine open-field test were systematically recorded every fourth day, starting with day 1 of treatment. The open field tests were given 2 or 10 h… (More)


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@article{Siwak2000BehavioralAE, title={Behavioral activating effects of adrafinil in aged canines.}, author={Christina T. Siwak and Philippe Gruet and Fr{\'e}d{\'e}rique Woehrl{\'e} and Matthias Schneider and Bruce A. Muggenburg and Heather L Murphey and Harry Callahan and Norton William Milgram}, journal={Pharmacology, biochemistry, and behavior}, year={2000}, volume={66 2}, pages={293-300} }