Behavioral Defects in Chaperone-Deficient Alzheimer's Disease Model Mice

@inproceedings{Ojha2011BehavioralDI,
  title={Behavioral Defects in Chaperone-Deficient Alzheimer's Disease Model Mice},
  author={Juhi Ojha and Rajalakshmi V. Karmegam and Jeyaraj Gunasingh Masilamoni and Alvin V. Terry and Anil Cashikar},
  booktitle={PloS one},
  year={2011}
}
Molecular chaperones protect cells from the deleterious effects of protein misfolding and aggregation. Neurotoxicity of amyloid-beta (Aβ) aggregates and their deposition in senile plaques are hallmarks of Alzheimer's disease (AD). We observed that the overall content of αB-crystallin, a small heat shock protein molecular chaperone, decreased in AD model mice in an age-dependent manner. We hypothesized that αB-crystallin protects cells against Aβ toxicity. To test this, we crossed αB-crystallin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…