Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

@article{Plenek2012BehavioralNA,
  title={Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats},
  author={T. P{\'a}len{\'i}{\vc}ek and M. Fuj{\'a}kov{\'a} and M. Brunovsky and J. Hor{\'a}{\vc}ek and I. Gorman and M. Bal{\'i}kov{\'a} and L. Rambousek and K. Syslov{\'a} and P. Ka{\vc}er and P. Zach and V. Buben{\'i}kov{\'a}-Vale{\vs}ov{\'a} and F. Tyl{\vs} and A. Kube{\vs}ov{\'a} and J. Puskar{\vc}{\'i}kov{\'a} and C. H{\"o}schl},
  journal={Psychopharmacology},
  year={2012},
  volume={225},
  pages={75-93}
}
  • T. Páleníček, M. Fujáková, +12 authors C. Höschl
  • Published 2012
  • Medicine, Psychology
  • Psychopharmacology
  • Rationale and objectivesBehavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined.Materials and methodsLocomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound.Results2C-B had a biphasic effect on locomotion with… CONTINUE READING
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