Behavioral, endocrine and immunological characteristics of a murine model of premature aging.

@article{PrezAlvarez2005BehavioralEA,
  title={Behavioral, endocrine and immunological characteristics of a murine model of premature aging.},
  author={Laura P{\'e}rez-Alvarez and Isabel Baeza and Lorena Arranz and Eva M. Marco and {\'E}rika Borcel and Carmen Guaza and Mar{\'i}a Paz Viveros and M{\'o}nica de la Fuente},
  journal={Developmental and comparative immunology},
  year={2005},
  volume={29 11},
  pages={965-76}
}
We have previously shown that differences in life span among members of Swiss mouse populations appear to be related to their exploration of a T-maze, with a slow exploration ('slow mice') being linked to alteration of spontaneous behavior and monoaminergic systems, impaired immune function and shorter life span. In general these traits resemble some of the characteristics of chronologically old animals. Thus, we proposed the 'slow mice' as a model of prematurely aging mice (PAM). Now, we have… CONTINUE READING

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