Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs

@article{Martin1991BehavioralBA,
  title={Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs},
  author={Billy R. Martin and David R Compton and Brian F. Thomas and William R. Prescott and Patrick J. Little and Raj Kumar Razdan and M.Ross Johnson and Lawrence S. Melvin and Raphael Mechoulam and J. WardSusan},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={40},
  pages={471-478}
}
Numerous cannabinoids have been synthesized that are extremely potent in all of the behavioral assays conducted in our laboratory. An important feature in increasing potency has been the substitution of a dimethylheptyl (DMH) side chain for the pentyl side chain. Our previous studies have shown that (-)-11-OH-delta 8-THC-dimethylheptyl was 80-1150 times more potent than delta 9-THC. Stereospecificity was demonstrated by its (+)-enantiomer which was more than 1400-7500 times less potent. A… Expand
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