Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory1

@inproceedings{Sutton2002BehavioralCA,
  title={Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory1},
  author={Michael A Sutton and Thomas J. Carew},
  booktitle={Integrative and comparative biology},
  year={2002}
}
Abstract Serotonin (5HT) induces short-term and long-term synaptic facilitation (STF and LTF, respectively) at sensory neuron to motor neuron (SN-MN) synapses in Aplysia, and these forms of plasticity are thought to contribute to short-term and long-term memory for behavioral sensitization. Recent evidence in Aplysia has identified a third phase of synaptic facilitation—intermediate-term facilitation (ITF)—that is temporally and mechanistically distinct from STF and LTF. Here, we review the… 
Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia II: Long-Term Facilitation1
TLDR
The results show that two anatomically remote cellular compartments can functionally interact within a surprisingly short time period and that there are multiple forms of both ITF and LTF that differ in their induction and expression requirements, and at least in some instances, the different temporal phases of facilitation, and perhaps comparable phases of memory, can be induced independently of each other.
Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.
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Data support the hypothesis that sensory neuron activity coincident with the last RT training trial is sufficient to convert the molecular signaling already established by RT training into an AD-like molecular phenotype.
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TLDR
Evidence is provided that MAPK plays important roles specifically in long-lasting phases of synaptic plasticity and memory.
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  • 2011
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Studies in a simple invertebrate model system have and will continue to provide critical mechanistic insights to complementary processes in higher organisms, highlighting the evolutionary importance of the circadian clock on metabolic, physiological, and behavioral processes.
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The potential role of postsynaptic phospholipase C activity in synaptic facilitation and behavioral sensitization in Aplysia.
TLDR
It is found that PLC activity is required for synaptic facilitation following a 10-min treatment with 5- HT, as measured at 20 min after 5-HT washout, and injecting U73122 into intact animals before behavioral training impaired intermediate-term sensitization.
Habituation in Aplysia: The Cheshire Cat of neurobiology
  • D. Glanzman
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Identification and Characterization of AplysiaAdducin, an Aplysia Cytoskeletal Protein Homologous to Mammalian Adducins: Increased Phosphorylation at a Protein Kinase C Consensus Site during Long-Term Synaptic Facilitation
TLDR
Cloned Aplysia adducin is modulated specifically with later phases of LTF and provides an attractive candidate protein that contributes to structural changes accompanying long-lasting synaptic alteration.
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References

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Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia II: Long-Term Facilitation1
TLDR
The results show that two anatomically remote cellular compartments can functionally interact within a surprisingly short time period and that there are multiple forms of both ITF and LTF that differ in their induction and expression requirements, and at least in some instances, the different temporal phases of facilitation, and perhaps comparable phases of memory, can be induced independently of each other.
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The hypothesis that LTF is not a simple elaboration of STF is supported, raising the possibility that STF, ITF, and LTF may reflect components of different memory phases in the intact animal.
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TLDR
It is reported that a protocol producing long-term sensitization results in a decrease in the amount of regulatory subunits of the cAMP-dependent protein kinase in animals 24 h after training, with no effect on the catalytic subunit.
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TLDR
This work examines how two forms of facilitation interact at the level of an individual synaptic connection by using a culture preparation consisting of a single bifurcated sensory neuron that forms independent synaptic contacts with each of two spatially separated motor neurons and finds that the homosynaptic facilitation produced by a train of action potentials is cell wide and is evident at all of the terminals of the sensory neuron.
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TLDR
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TLDR
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