Behavior of endothelial cells on Matrigel and development of a method for a rapid and reproducible in vitro angiogenesis assay

@article{Crabtree2007BehaviorOE,
  title={Behavior of endothelial cells on Matrigel and development of a method for a rapid and reproducible in vitro angiogenesis assay},
  author={Benedict Crabtree and Vasanta Subramanian},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2007},
  volume={43},
  pages={87-94}
}
During the process of angiogenesis, the normally quiescent endothelial cells that line the vasculature are induced to proliferate, migrate and align to form new blood vessels by angiogenic stimuli. Assays for angiogenic factors mostly involve in vivo approaches. The two most commonly used in vivo assays—the chick chorioallantoic membrane (CAM) assay and the rabbit corneal assay are tedious to perform and are technically demanding. Several in vitro assays have also been developed, based on the… CONTINUE READING
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