Behavior of circulating epithelial tumor cells ( CETC ) and FISH ( fluorescence in situ hybridisation ) of epidermal growth factor receptor ( EGFR )-gene amplification in lung cancer patients during the course of therapy

@inproceedings{Sherif2013BehaviorOC,
  title={Behavior of circulating epithelial tumor cells ( CETC ) and FISH ( fluorescence in situ hybridisation ) of epidermal growth factor receptor ( EGFR )-gene amplification in lung cancer patients during the course of therapy},
  author={M. H. E. Sherif and Claus Peter Schneider and Carola Rabenstein and Amina Hessein Hassab and Magdy Mamdouh El Bordiny and Mona Wagdy Ayad and Katharine Pachmann},
  year={2013}
}
Introduction: Monitoring the response of CETC to therapy in lung cancer allows early detection of patients at risk of progression. Analysis of the EGFR-gene amplification in these cells may help to characterize patients who might benefit from tyrosine kinase inhibitors. Methods: CETCs were quantified at least twice during treatment from blood of 52 patients with advanced non small cell lung cancer (NSCLC) using fluorescence labelled anti-EpCAM. EGFR-gene amplification was analysed in these… CONTINUE READING