Behavior of cholesterol and its effect on head group and chain conformations in lipid bilayers: a molecular dynamics study.

@article{Robinson1995BehaviorOC,
  title={Behavior of cholesterol and its effect on head group and chain conformations in lipid bilayers: a molecular dynamics study.},
  author={Alan J. Robinson and William Graham Richards and Peter J. Thomas and Michael M. Hann},
  journal={Biophysical journal},
  year={1995},
  volume={68 1},
  pages={164-70}
}
Cholesterol molecules were put into a computer-modeled hydrated bilayer of dimyristoyl phosphatidyl choline molecules, and molecular dynamics simulations were run to characterize the effect of this important molecule on membrane structure and dynamics. The effect was judged by observing differences in order parameters, tilt angles, and the fraction of gauche bonds along the hydrocarbon chains between lipids adjacent to cholesterol molecules and comparing them with those further away. It was… CONTINUE READING
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