Behavior and clinical relevance of histamine and leukotrienes C4 and B4 in grass pollen-induced rhinitis.

@article{Miadonna1987BehaviorAC,
  title={Behavior and clinical relevance of histamine and leukotrienes C4 and B4 in grass pollen-induced rhinitis.},
  author={Antonio Miadonna and Alberto Tedeschi and Ennio Leggieri and Maurizio Lorini and G. C. Folco and Angelo Sala and R M Qualizza and M. Froldi and Carlo Zanussi},
  journal={The American review of respiratory disease},
  year={1987},
  volume={136 2},
  pages={357-62}
}
The release kinetics of histamine and leukotrienes C4 (LTC4) and B4 (LTB4) were investigated in nasal secretions of 10 patients with hay fever after antigen challenge. High levels of biologically active histamine were found in nasal washes from asymptomatic allergic and normal subjects. With repeated lavages, the amount of histamine recovered dropped markedly. Grass pollen challenge was followed by a significant (p less than 0.05) dose-dependent and time-limited (5 min) increase in histamine… CONTINUE READING

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