Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease

@article{Luchtman2009BehaviorNA,
  title={Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease},
  author={Dirk W. Luchtman and Di Shao and Cai Song},
  journal={Physiology & Behavior},
  year={2009},
  volume={98},
  pages={130-138}
}
Three common dosing regimens of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of Parkinson's disease (PD) were compared in C57BL/6 mice on behavior, striatal and extra-striatal neurotransmission, and brain cytokines, to clarify the differences between regimens on these variables. Acute regimen: Rotorod performance and open field grooming were decreased. Striatal dopamine (DA) was depleted, but DA turnover increased. Striatal noradrenalin (NA), frontal cortex serotonin (5… CONTINUE READING

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