Beginning of the end of two-stage theory purporting that inflammation then degeneration explains pathogenesis of progressive multiple sclerosis.

@article{Steinman2016BeginningOT,
  title={Beginning of the end of two-stage theory purporting that inflammation then degeneration explains pathogenesis of progressive multiple sclerosis.},
  author={Lawrence Steinman and Scott S. Zamvil},
  journal={Current opinion in neurology},
  year={2016},
  volume={29 3},
  pages={340-4}
}
PURPOSE OF REVIEW The review discusses future directions in research on multiple sclerosis and neuromyelitis optica, as long-held beliefs about these diseases are undermined with data from recent clinical trials. RECENT FINDINGS Results of clinical trials for registration (phase 3) were reported in the last year. Anti-inflammatory approaches, such as daclizumab high-yield process targeting IL-2 receptor, and ocrelizumab targeting CD20 B cells, confirmed a beneficial role of immune suppression… CONTINUE READING
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Immunomodulators and im- munosuppressants for relapsing-remitting multiple sclerosis: a network meta- analysis

  • I Tramacere, C Del Giovane, G Salanti
  • Cochrane Database Syst Rev 2015; 9:CD011381…
  • 2016
1 Excerpt

Simvastatin amelio- rates experimental autoimmune encephalomyelitis by inhibiting Th1/Th17 response and cellular infiltration

  • DM DeOliviera, EM Lobato DeOliviera, M Ferrari
  • Immunopharmacol
  • 2015
3 Excerpts

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

  • J Chattaway, N Schuerer, A Alsanousi
  • Lancet
  • 2014

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