Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. I. Biochemical profile.

@article{Curet1996BefloxatoneAN,
  title={Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. I. Biochemical profile.},
  author={Olivier Curet and Gabrielle Damoiseau and N Aubin and Nicole Sontag and Vincenzo Rovei and F X Jarreau},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={277 1},
  pages={
          253-64
        }
}
Befloxatone, a novel oxazolidinone derivative, inhibited selectively and competitively monoamine oxidase (MAO)-A in human and rat brain, heart, liver and duodenum homogenates with Ki values ranging from 1.9 to 3.6 nM for MAO-A and from 270 to 900 nM for MAO-B. In vitro, befloxatone was more potent at inhibiting MAO-A activity than reference compounds (befloxatone > harmaline > brofaromine > BW 137OU87 > RS 8359 > toloxatone > moclobemide). The inhibition of MAO-A by befloxatone was time… CONTINUE READING
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