Bef medaka mutant reveals the essential role of c-myb in both primitive and definitive hematopoiesis.

@article{Moriyama2010BefMM,
  title={Bef medaka mutant reveals the essential role of c-myb in both primitive and definitive hematopoiesis.},
  author={Akemi Moriyama and Keiji Inohaya and Kouichi Maruyama and Akira Kudo},
  journal={Developmental biology},
  year={2010},
  volume={345 2},
  pages={133-43}
}
Vertebrate hematopoiesis is characterized by two evolutionally conserved phases of development, i.e., primitive hematopoiesis, which is a transient phenomenon in the early embryo, and definitive hematopoiesis, which takes place in the later stages. Beni fuji (bef) was originally isolated as a medaka mutant that has an apparently reduced number of erythrocytes in its peripheral blood. Positional cloning revealed that the bef mutant has a nonsense mutation in the c-myb gene. Previous studies have… CONTINUE READING

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