Bee venom induces apoptosis through intracellular Ca2+ -modulated intrinsic death pathway in human bladder cancer cells.

@article{Ip2012BeeVI,
  title={Bee venom induces apoptosis through intracellular Ca2+ -modulated intrinsic death pathway in human bladder cancer cells.},
  author={S. -M. Ip and Yung-Lin Chu and C P Yu and Po-yuan Chen and Heng-Chien Ho and J. Yang and Hui-Ying Huang and F S Chueh and Tung-Yuan Lai and Jing-Gung Chung},
  journal={International journal of urology : official journal of the Japanese Urological Association},
  year={2012},
  volume={19 1},
  pages={61-70}
}
OBJECTIVES To focus on bee venom-induced apoptosis in human bladder cancer TSGH-8301 cells and to investigate its signaling pathway to ascertain whether intracellular calcium iron (Ca(2+)) is involved in this effect. METHODS Bee venom-induced cytotoxic effects, productions of reactive oxygen species and Ca(2+) and the level of mitochondrial membrane potential (ΔΨm) were analyzed by flow cytometry. Apoptosis-associated proteins were examined by Western blot analysis and confocal laser… CONTINUE READING

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