Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system.

  title={Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system.},
  author={Gabriela Torrea and Nele Coeck and Christel Desmaretz and Tim Van De Parre and Tijs Van Poucke and Nacer Lounis and Bouke Catherine de Jong and Leen Rigouts},
  journal={The Journal of antimicrobial chemotherapy},
  volume={70 8},
OBJECTIVES The objective of this study was to evaluate the performance of the BACTEC MGIT960 system to test the susceptibility to bedaquiline for Mycobacterium tuberculosis complex. METHODS We determined the quality control (QC) range of bedaquiline using the M. tuberculosis H37Rv reference strain and the epidemiological cut-off (ECOFF) in MGIT960 and on Middlebrook 7H11 agar (M7H11) using 47 strains from bedaquiline treatment-naive patients. The accuracy of MGIT960 was evaluated versus M7H11… CONTINUE READING
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Conditions affecting the minimal inhibitory concentration (MIC) of bedaquiline against Mycobacterium tuberculosis

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