Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis.

  title={Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis.},
  author={Elias B Chahine and Lamis R Karaoui and Hanine Mansour},
  journal={The Annals of pharmacotherapy},
  volume={48 1},
OBJECTIVE To review the chemistry, pharmacology, microbiology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, dosage, and administration of bedaquiline, a novel oral diarylquinoline antimycobacterial agent approved by the Food and Drug Administration for the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB). DATA SOURCES A search of PubMed (January 2004-May 2013) and International Pharmaceutical Abstracts (January 2004-May 2013) using the search… CONTINUE READING