Becoming pandemic

VOLUME 14 NUMBER 7 JULY 2013 NATURE IMMUNOLOGY Systemic alarmin Cochlin, a glycosylated extracellular matrix protein found in the inner ear, is also expressed in the spleen, but its physiological role there remains unknown. In Immunity, Py et al. show cochlin is secreted by follicular DCs. After bacterial infection, cochlin is proteolytically cleaved by… CONTINUE READING