Becoming adaptive

Abstract

Glucocorticoids are anti-inflammatory factors that repress inducible gene expression dependent on the transcription factors NF-kB and AP-1. In the Proceedings of the National Academy of Science, Gupte et al. show that binding of ligand by the nuclear glucocorticoid receptor (GR) represses two classes of inflammatory signal–dependent gene transcription. GR… (More)
DOI: 10.1038/ni.2726

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