Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

@article{Liang2008Beclin1bindingUT,
  title={Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking},
  author={Chengyu Liang and Jong-soo Lee and Kyung-Soo Inn and Michaela U Gack and Qinglin Li and Esteban A. Roberts and Isabelle Vergne and Vojo Deretic and Pinghui Feng and Chihiro Akazawa and Jae U Jung},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={776-787}
}
Autophagic and endocytic pathways are tightly regulated membrane rearrangement processes that are crucial for homeostasis, development and disease. Autophagic cargo is delivered from autophagosomes to lysosomes for degradation through a complex process that topologically resembles endosomal maturation. Here, we report that a Beclin1-binding autophagic tumour suppressor, UVRAG, interacts with the class C Vps complex, a key component of the endosomal fusion machinery. This interaction stimulates… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 256 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

molecular mechanisms and biological functions of autophagy

  • B. Levine, Klionsky, D. J. Development by self-digestion
  • Dev. Cell 6, 463–477
  • 2004
Highly Influential
10 Excerpts

Similar Papers

Loading similar papers…