Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

@article{Liu2011Beclin1CT,
  title={Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13},
  author={Junli Liu and Hongguang Xia and Minsu Kim and Lihua Xu and Ying Li and Lihong Zhang and Yu Cai and Helin Vakifahmetoglu Norberg and Tao Zhang and Tsuyoshi Furuya and Minzhi Jin and Zhimin Zhu and Huanchen Wang and Jia Huan Yu and Yanxia Li and Yan Hao and Augustine M. K. Choi and Hengming Ke and Dawei Ma and Junying Yuan},
  journal={Cell},
  year={2011},
  volume={147},
  pages={223-234}
}
Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named "spautin-1" for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Beclin1 is a tumor suppressor and frequently monoallelically… CONTINUE READING
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