Beclin-1 Targeting for Viral Immune Escape

  title={Beclin-1 Targeting for Viral Immune Escape},
  author={Christian M{\"u}nz},
Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4(+) T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit autophagosome generation or maturation. Interestingly, most of the respective viral proteins exert these functions via binding to Beclin-1, an… CONTINUE READING


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