Becatamide Found in Houttuynia cordata Suppresses P‐selectin Expression Via Inhibiting COX Enzyme, Not Increasing cAMP in Platelets

@article{Park2015BecatamideFI,
  title={Becatamide Found in Houttuynia cordata Suppresses P‐selectin Expression Via Inhibiting COX Enzyme, Not Increasing cAMP in Platelets},
  author={J. Park},
  journal={Phytotherapy Research},
  year={2015},
  volume={29},
  pages={1381 - 1387}
}
  • J. Park
  • Published 2015
  • Chemistry, Medicine
  • Phytotherapy Research
Atherosclerosis is a well‐known inflammatory cardiovascular disease. Recent studies suggested potential anti‐atherosclerosis effects of becatamide found in Houttuynia cordata. Therefore, in this study, we investigated potential effect of becatamide (1) and its analogues (enferamide (2), veskamide (3), oretamide (4) and amkamide (5)) on cyclooxygenase (COX)‐1 and ‐2 and the production of cyclic adenosine monophosphate (cAMP), which are critically involved in platelet activation. Among them… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
Protective effects of veskamide, enferamide, becatamide, and oretamide on H2O2-induced apoptosis of PC-12 cells.
  • J. Park
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2011
Clovamide-Type Phenylpropenoic Acid Amides, N-Coumaroyldopamine and N-Caffeoyldopamine, Inhibit Platelet-Leukocyte Interactions via Suppressing P-Selectin Expression
  • J. Park, N. Schoene
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • 2006
The role of PGE2 in human atherosclerotic plaque on platelet EP3 and EP4 receptor activation and platelet function in whole blood
Aspirin inhibits surface glycoprotein IIb/IIIa, P‐selectin, CD63, and CD107a receptor expression on human platelets
Anti-platelet therapy: phosphodiesterase inhibitors.
The Evolution of Antiplatelet Therapy in the Treatment of Acute Coronary Syndromes
...
1
2
3
4
...