Beating the odds: BETs in disease.

@article{Wang2015BeatingTO,
  title={Beating the odds: BETs in disease.},
  author={Chen-Yi Wang and Panagis Filippakopoulos},
  journal={Trends in biochemical sciences},
  year={2015},
  volume={40 8},
  pages={468-79}
}
Bromodomains (BRDs) are evolutionarily conserved protein interaction modules that specifically recognise acetyl-lysine on histones and other proteins, facilitating roles in regulating gene transcription. BRD-containing proteins bound to chromatin loci such as enhancers are often deregulated in disease leading to aberrant expression of proinflammatory cytokines and growth-promoting genes. Recent developments targeting the bromo and extraterminal (BET) subset of BRD proteins demonstrated… CONTINUE READING
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