Bead compacts. I. Effect of compression on maintenance of polymer coat integrity in multilayered bead formulations.

@article{Altaf1998BeadCI,
  title={Bead compacts. I. Effect of compression on maintenance of polymer coat integrity in multilayered bead formulations.},
  author={Syed A. Altaf and Stephen W. Hoag and J. W. Ayres},
  journal={Drug development and industrial pharmacy},
  year={1998},
  volume={24 8},
  pages={737-46}
}
Little information is available on the compactability of beads for oral sustained-release dosage forms. It is known that polymer-coated beads may fuse together to produce a non-disintegrating controlled-release matrix tablet when compressed. This study evaluates the effect of compression on beads with multiple layers of polymer and drug coat, and the effect of cushioning excipients and compaction pressure on drug release from compressed bead formulations. The multilayered beads consist of… CONTINUE READING

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