Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.

@article{Numata1999BdpAN,
  title={Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.},
  author={Shin-ichiro Numata and Pier Paolo Claudio and Charity L Dean and Antonio Giordano and Carlo M. Croce},
  journal={Cancer research},
  year={1999},
  volume={59 15},
  pages={3741-7}
}
We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional… CONTINUE READING

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