Bcr-Abl is a “Molecular Switch” for the Decision for Growth and Differentiation in Hematopoietic Stem Cells

@article{Era2002BcrAblIA,
  title={Bcr-Abl is a “Molecular Switch” for the Decision for Growth and Differentiation in Hematopoietic Stem Cells},
  author={T. Era},
  journal={International Journal of Hematology},
  year={2002},
  volume={76},
  pages={35-43}
}
  • T. Era
  • Published 2002
  • Medicine, Biology
  • International Journal of Hematology
  • Chronic myeloid leukemia (CML) is a clonal disorder originating in the pluripotent hematopoietic stem cell (HSC), the hallmark of which is the constitutively activated p210-type of Bcr-Abl tyrosine kinase protein. Studies in recent years have helped us to understand the molecular processes involved in the initiation and progression of CML. Although a great amount of knowledge has been accumulated, the effect of Bcr-Abl on the HSC is still unclear. We have developed an in vitro system that… CONTINUE READING
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