Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3.

@article{AmaranteMendes1998BcrAblEI,
  title={Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3.},
  author={Gustavo Pessini Amarante-Mendes and C Naekyung Kim and Lili Liu and Y Huang and Cheryl Perkins and Douglas R Green and Kapil Bhalla},
  journal={Blood},
  year={1998},
  volume={91 5},
  pages={1700-5}
}
Bcr-Abl expression in leukemic cells is known to exert a potent effect against apoptosis due to antileukemic drugs, but its mechanism has not been elucidated. Recent reports have indicated that a variety of apoptotic stimuli cause the preapoptotic mitochondrial release of cytochrome c (cyt c) into cytosol, which mediates the cleavage and activity of caspase… CONTINUE READING