Bcr-Abl and inhibition of apoptosis in chronic myelogenous leukemia cells

@article{FernndezLuna2000BcrAblAI,
  title={Bcr-Abl and inhibition of apoptosis in chronic myelogenous leukemia cells},
  author={Jos{\'e} L Fern{\'a}ndez-Luna},
  journal={Apoptosis},
  year={2000},
  volume={5},
  pages={315-318}
}
Chronic myelogenous leukemia (CML) cells are highly resistant to apoptosis induced by chemotherapeutic drugs. The observation that production of Bcr-Abl is the initiating event in CML has focussed attention on the survival signals triggered by this oncogene. A number of signal transducers and transcription factors have been associated with the antiapoptotic phenotype of CML cells, some of which lead to the expression and/or activation of members of the Bcl-2 family of apoptosis modulators, such… CONTINUE READING

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