BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation.

@article{Kaluzhny2002BclxLOI,
  title={BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation.},
  author={Yulia Kaluzhny and Guangyao Yu and Shishinn Sun and Paul A. Toselli and Bernhard Nieswandt and Carl W. Jackson and Katya Ravid},
  journal={Blood},
  year={2002},
  volume={100 5},
  pages={1670-8}
}
Fragmentation of polyploid megakaryocytes into platelets has great relevance for blood homeostasis. Apoptotic cell death is a highly regulated genetic program, which has been observed in mature megakaryocytes fragmenting into platelets. The antiapoptotic protein BclxL has been reported as up-regulated during megakaryocytic differentiation in vitro, but absent during late megakaryopoiesis. Our study focused on examining BclxL levels in megakaryocytes in vivo and in assessing the effect of its… CONTINUE READING