Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.

@article{Stegh2008Bcl2L12mediatedIO,
  title={Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.},
  author={Alexander H. Stegh and Santosh Kesari and John E. Mahoney and Harry T. Jenq and Kristin L. Forloney and Alexei Protopopov and David N Louis and Lynda Chin and Ronald A. Depinho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 31},
  pages={10703-8}
}
Glioblastoma multiforme (GBM) is a highly aggressive brain cancer that is characterized by the paradoxical features of intense apoptosis resistance yet a marked propensity to undergo necrosis. Bcl2L12 (for Bcl2-Like12) is a nuclear and cytoplasmic oncoprotein that is universally overexpressed in primary GBM and functions to block postmitochondrial apoptosis signaling by neutralizing effector caspase-3 and caspase-7 maturation. This postmitochondrial block in apoptosis engenders the alternate… CONTINUE READING
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