Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study.

@article{Briasoulis1998Bcl2AP,
  title={Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study.},
  author={Evangelos Briasoulis and Maria G Tsokos and George Fountzilas and Dimitrios I. Bafaloukos and Paris A. Kosmidis and Epaminontas Samantas and Dimosthenis Skarlos and C. Nicholas Boothwyn Nicolaides and Nicholas Pavlidis},
  journal={Anticancer research},
  year={1998},
  volume={18 3B},
  pages={
          1907-14
        }
}
We have previously shown that metastatic carcinomas of unknown primary site overexpress several tumor markers as well as the products of the oncogenes c-myc, ras and c-erbB2. We analyzed the tissue expression of the protein products of the apoptosis modulation genes p53 and bcl-2 in 47 CUP cases. Formalin-fixed, paraffin embedded tumor specimens were stained with commercially available antibodies to p53 (DO7) and bcl-2 after antigen retrieval by the microwave method. Staining was evaluated by… CONTINUE READING

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