Bcl-xL regulates xenophagy by inhibiting the autophagosome-lysosome fusion and bacterial internalization through the Beclin 1-UVRAG complex

  title={Bcl-xL regulates xenophagy by inhibiting the autophagosome-lysosome fusion and bacterial internalization through the Beclin 1-UVRAG complex},
  author={Shintaro Nakajima},
Starvation-induced autophagy is regulated by a directly interaction between anti-apoptotic proteins Bcl-2/Bcl-xL and autophagy-related protein Beclin 1. Beclin 1 is also considered to involve in multiple vesicle trafficking pathways such as autophagosome elongation and endocytosis by binding to Atg14L and UVRAG. However, precise roles of Bcl-2/Bcl-xL-Beclin 1 complex in anti-bacterial autophagy (xenophagy) are poorly understood. Recently, we reported that Bcl-xL but not Bcl-2 regulates… Expand

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