Bcl-xL regulates xenophagy by inhibiting the autophagosome-lysosome fusion and bacterial internalization through the Beclin 1-UVRAG complex

@inproceedings{Nakajima2017BclxLRX,
  title={Bcl-xL regulates xenophagy by inhibiting the autophagosome-lysosome fusion and bacterial internalization through the Beclin 1-UVRAG complex},
  author={Shintaro Nakajima},
  year={2017}
}
Starvation-induced autophagy is regulated by a directly interaction between anti-apoptotic proteins Bcl-2/Bcl-xL and autophagy-related protein Beclin 1. Beclin 1 is also considered to involve in multiple vesicle trafficking pathways such as autophagosome elongation and endocytosis by binding to Atg14L and UVRAG. However, precise roles of Bcl-2/Bcl-xL-Beclin 1 complex in anti-bacterial autophagy (xenophagy) are poorly understood. Recently, we reported that Bcl-xL but not Bcl-2 regulates… Expand

Figures from this paper

References

SHOWING 1-10 OF 36 REFERENCES
Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG
TLDR
Results indicate that Bcl-xL inhibits GAS-induced autophagy directly by suppressing autophagosome-lysosome fusion and indirectly by suppressing GAS internalization via interaction with Beclin 1-UVRAG. Expand
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
TLDR
Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death. Expand
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex
TLDR
It is hypothesized that by forming distinct protein complexes, Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps. Expand
Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking
TLDR
This study demonstrates that Atg14L functions as a multivalent trafficking effector that regulates endosome maturation as well as autophagosome formation, reflecting the complexity of the crosstalk between autophagic and endocytic vesicle trafficking in higher eukaryotes. Expand
Induction of autophagy and inhibition of tumorigenesis by beclin 1
TLDR
It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies. Expand
The autophagy effector Beclin 1: a novel BH3-only protein
TLDR
The evidence that the BH3 domain of Beclin 1 serves as a key structural motif that enables Bcl-2 to function not only as an antiapoptotic protein, but also as an antiautophagy protein is summarized. Expand
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
TLDR
Findings argue against a role for Beclin 1 as an essential chaperone or adaptor for hVps34 in normal vesicular trafficking, and support the hypothesis that BeClin 1 functions mainly to engage hVPS34 in the autophagic pathway. Expand
Divergent roles of BECN1 in LC3 lipidation and autophagosomal function
TLDR
The results demonstrate the essential role of BECN1 in the functional formation of autophagosomes, but not in LC3B lipidation, and confirm that the PtdIns3K complex activity and autophagy flux were disrupted in B ECN1−/− cells. Expand
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
TLDR
It is reported that a Beclin1-binding autophagic tumour suppressor, UVRAG, interacts with the class C Vps complex, a key component of the endosomal fusion machinery, and this interaction stimulates Rab7 GTPase activity and autophagosome fusion with late endosomes/lysosomes, thereby enhancing delivery and degradation of Autophagic cargo. Expand
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
TLDR
The data suggest that the Beclin 1–hVps34 complex functions in two different steps of autophagy by altering the subunit composition, as well as enhancement of endocytic trafficking. Expand
...
1
2
3
4
...