Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis.

@article{Liu1998BclxLIE,
  title={Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis.},
  author={Jingyao Liu and B Fletcher and Carmen Page and Chun-jie Hu and Gabriel N{\'u}{\~n}ez and Vikki Baker},
  journal={Gynecologic oncology},
  year={1998},
  volume={70 3},
  pages={398-403}
}
OBJECTIVE To investigate the role of Bcl-xL in resistance to chemotherapy-induced apoptosis in ovarian carcinoma. METHODS Two human ovarian carcinoma cell lines were used in this study: A2780 and SKOV3. A2780 cells were transfected with human Bcl-xL or control plasmid alone. Expression of Bcl-xL in single cell clones was analyzed by flow cytometry and protein expression was confirmed by Western blot. For in vitro chemotherapy-induced death assays, cisplatin and Taxol were used. The percentage… CONTINUE READING
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