Bcl-xL controls a switch between cell death modes during mitotic arrest

@inproceedings{Bah2014BclxLCA,
  title={Bcl-xL controls a switch between cell death modes during mitotic arrest},
  author={Nourdine Bah and Laurent Maillet and Jeremy Ryan and S Dubreil and Fabien Gautier and Anthony Letai and Philippe Juin and Sophie Barill{\'e}-Nion},
  booktitle={Cell Death and Disease},
  year={2014}
}
Antimitotic agents such as microtubule inhibitors (paclitaxel) are widely used in cancer therapy while new agents blocking mitosis onset are currently in development. All these agents impose a prolonged mitotic arrest in cancer cells that relies on sustained activation of the spindle assembly checkpoint and may lead to subsequent cell death by incompletely understood molecular events. We have investigated the role played by anti-apoptotic Bcl-2 family members in the fate of mitotically arrested… CONTINUE READING