Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy.

@article{Chien2007BclxLAP,
  title={Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy.},
  author={C Y Chien and Song-Kuen Shyue and M Lai},
  journal={Transplantation},
  year={2007},
  volume={84 9},
  pages={1183-90}
}
BACKGROUND Apoptosis and autophagy may contribute to cell homeostasis in the kidney subjected to ischemia/reperfusion injury via mitochondrial injury. Ischemia/reperfusion induces differential sensitivity between proximal and distal tubules via a dissociated Bcl-xL expression. We hypothesized Bcl-xL augmentation in the proximal and distal tubules may potentially reduce ischemia/reperfusion induced renal dysfunction. METHODS We augmented Bcl-xL protein expression in the kidney with intrarenal… CONTINUE READING
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