Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells.

@article{Terui1998BclxIA,
  title={Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells.},
  author={Yasuhito Terui and Yusuke Furukawa and Jiro Kikuchi and Satsuki Iwase and Kiyohiko Hatake and Yasusada Miura},
  journal={Experimental hematology},
  year={1998},
  volume={26 3},
  pages={236-44}
}
Differentiation- and lineage-related differences in the expression of two anti-apoptotic molecules, bcl-x and bcl-2, were examined using various human hematopoietic cell lines. Bcl-x was strongly expressed in cell lines with erythroid and megakaryocytic properties (K562, HEL, CMK, and Mo7E), and was moderately expressed in immature myeloid cell lines (KG-1 and KCL-22). Bcl-2 expression was relatively weak in these cells. On the other hand, bcl-x was not expressed in more mature myeloid cell… CONTINUE READING
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