Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1.

  title={Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1.},
  author={Seung Baek Lee and Hyung Jung Kim and Jungar Shin and Sung Tae Kang and Seongman Kang and Young Do Yoo},
  journal={Oncology reports},
  volume={25 5},
B-cell lymphoma-extra large (Bcl-XL) has been known to suppress serum deprivation-induced cell death, while reactive oxygen species modulator 1 (Romo1) is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS). Therefore, we investigated whether Bcl-XL expression could inhibit the serum deprivation-induced increase in ROS and cell death, which are mediated by Romo1. We found that Bcl-XL expression effectively blocked serum deprivation- and Romo1-triggered ROS… CONTINUE READING


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