Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors.

@article{Li2002BclXLAC,
  title={Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors.},
  author={Chi Jia Li and Casey John Fox and Stephen R. Master and Vytautas Petras. Bindokas and Lewis A. Chodosh and Craig B Thompson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 15},
  pages={
          9830-5
        }
}
An oligonucleotide-based microarray analysis of 9,500 genes and expressed sequence tags (ESTs) demonstrated that the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R) was significantly down-regulated in Bcl-X(L)-expressing as compared with control cells. This result was confirmed at the mRNA and protein levels by Northern and Western blot analyses of two independent hematopoietic cell lines and murine primary T cells. Bcl-X(L) expression resulted in a dose-dependent decrease in IP(3)R… CONTINUE READING
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