Bcl-2 sensitive mitochondrial potassium accumulation and swelling in apoptosis.

@article{Eliseev2002Bcl2SM,
  title={Bcl-2 sensitive mitochondrial potassium accumulation and swelling in apoptosis.},
  author={Roman A Eliseev and Karlene K Gunter and Thomas E. Gunter},
  journal={Mitochondrion},
  year={2002},
  volume={1 4},
  pages={361-70}
}
During etoposide-induced apoptosis in HL-60 cells, cytochrome c release was associated with mitochondrial swelling caused by increased mitochondrial potassium uptake. The mitochondrial permeability transition was also observed; however, it was not the primary cause of mitochondrial swelling. Potassium uptake and swelling of mitochondria were blocked by bcl-2 overexpression. As a result, cytochrome c release was reduced, and apoptosis delayed. Residual cytochrome c release in the absence of… CONTINUE READING