Bcl-2 proteins in development, health, and disease of the hematopoietic system.

@article{Kollek2016Bcl2PI,
  title={Bcl-2 proteins in development, health, and disease of the hematopoietic system.},
  author={Matthias Kollek and A Peer - Reviewed Publication Written by Diane R. Mueller and Alexander Egle and Miriam Erlacher},
  journal={The FEBS journal},
  year={2016},
  volume={283 15},
  pages={2779-810}
}
Members of the Bcl-2 protein family regulate cell fate decisions following a variety of developmental cues or stress signals, with the outcomes of cell death or survival, thus shaping multiple mammalian tissues. This review describes in detail how anti- and proapoptotic Bcl-2 proteins contribute to the development and functioning of the fetal and adult hematopoietic systems and how they influence the generation and maintenance of different hematopoietic lineages. An overview on how stress… CONTINUE READING
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