Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.

@article{Vaux1992Bcl2PD,
  title={Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.},
  author={David L. Vaux and Hector Leonardo Aguila and Irving L Weissman},
  journal={International immunology},
  year={1992},
  volume={4 7},
  pages={821-4}
}
'Programmed cell death' has been used to describe the death of cells killed by cytotoxic T cells or growth factor deprivation. Although bcl-2 can prevent death of cells deprived of growth factor, it failed to protect cells against T cell killing. In spite of bcl-2 expression, the DNA of targeted cells was degraded into nucleosome-sized fragments. Therefore… CONTINUE READING