Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux.

  title={Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux.},
  author={Shigeomi Shimizu and Yutaka Eguchi and Wataru Kamiike and Yoshimitsu Funahashi and Alexandre Mignon and Virginie Lacronique and Hikaru Matsuda and Yoshihide Tsujimoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 4},
We and others have recently shown that loss of the mitochondrial membrane potential (Deltapsi) precedes apoptosis and chemical-hypoxia-induced necrosis and is prevented by Bcl-2. In this report, we examine the biochemical mechanism used by Bcl-2 to prevent Deltapsi loss, as determined with mitochondria isolated from a cell line overexpressing human Bcl-2 or from livers of Bcl-2 transgenic mice. Although Bcl-2 had no effect on the respiration rate of isolated mitochondria, it prevented both… CONTINUE READING
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