Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.

  title={Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.},
  author={Laurent Monney and I den Otter and Reynald Olivier and Ulla Ravn and H Mirzasaleh and Isabelle Fellay and Guy G. Poirier and Christoph Borner},
  journal={Biochemical and biophysical research communications},
  volume={221 2},
The C. elegans gene product ced-9 inhibits programmed cell death by negatively regulating the death-mediating protease ced-3. The mammalian homolog of ced-9 is the oncoprotein Bcl-2. Overexpression of Bcl-2 spares mammalian and nematodal cells from dying and prevents ectopic cell death in ced-9 loss-of-function mutants. Although Bcl-2 has been shown to act as an antioxidant under certain conditions, additional functions have emerged from studies under low oxygen pressure. Here we show that Bcl… CONTINUE READING


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