Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins.

@article{Thomenius2003Bcl2OT,
  title={Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins.},
  author={Michael J. Thomenius and Nancy S Wang and Edmunds Z. Reineks and Zhengqi Wang and Clark W. Distelhorst},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 8},
  pages={6243-50}
}
Bcl-2 family members have been shown to be key mediators of apoptosis as either pro- or anti-apoptotic factors. It is thought that both classes of Bcl-2 family members act at the level of the mitochondria to regulate apoptosis, although the founding anti-apoptotic family member, Bcl-2 is localized to the endoplasmic reticulum (ER), mitochondrial, and nuclear membranes. In order to better understand the effect of Bcl-2 localization on its activity, we have utilized a Bcl-2 mutant that localizes… CONTINUE READING