Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

@article{Vaux1988Bcl2GP,
  title={Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells},
  author={D. Vaux and S. Cory and J. Adams},
  journal={Nature},
  year={1988},
  volume={335},
  pages={440-442}
}
  • D. Vaux, S. Cory, J. Adams
  • Published 1988
  • Biology, Medicine
  • Nature
  • A common feature of follicular lymphoma, the most prevalent haematological malignancy in humans, is a chromosome translocation (t(14;18)) that has coupled the immunoglobulin heavy chain locus to a chromosome 18 gene denoted bcl-2 (refs 1–6). By analogy with the translocated c-myc oncogene in other B-lymphoid tumours (reviewed in ref. 7), bcl-2 is a candidate oncogene, but no biological effects of bcl-2 have yet been reported. To test whether bcl-2 influences the growth of haematopoietic cells… CONTINUE READING
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