Bcl-2 family regulation of neuronal development and neurodegeneration.

@article{Akhtar2004Bcl2FR,
  title={Bcl-2 family regulation of neuronal development and neurodegeneration.},
  author={Rizwan S Akhtar and Jayne M. Ness and Kevin A. Roth},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1644 2-3},
  pages={189-203}
}
Neuronal cell death is a key feature of both normal nervous system development and neuropathological conditions. The Bcl-2 family, via its regulation of both caspase-dependent and caspase-independent cell death pathways, is uniquely positioned to critically control neuronal cell survival. Targeted gene disruptions of specific bcl-2 family members and the generation of transgenic mice overexpressing anti- or pro-apoptotic Bcl-2 family members have confirmed the importance of the Bcl-2 family in… CONTINUE READING

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