Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?

@inproceedings{Williams2015Bcl2FP,
  title={Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?},
  author={Michelle M. Williams and Rebecca S. Cook},
  booktitle={Oncotarget},
  year={2015}
}
Apoptosis, cell death executed by caspases, is essential to normal breast development and homeostasis. Pro-apoptotic and anti-apoptotic signals are tightly regulated in normal breast epithelial cells. Dysregulation of this balance is required for breast tumorigenesis and increases acquired resistance to treatments, including molecularly targeted therapies, radiation and chemotherapies. The pro-apoptotic or anti-apoptotic Bcl-2 family members interact with each other to maintain mitochondrial… CONTINUE READING
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